Distinct p53 isoforms code for opposing transcriptional outcomes 

ABSTRACT: p53 genes across species are broadly conserved and encode well-characterized transcriptional activators that specify inductive stress-responses. In some contexts, p53 can also down-regulate genes but the mechanisms involved are not understood and assumed to be indirect. Here we integrate synthetic and native cis-regulatory elements with an imaging platform to examine features of p53-mediated gene control in vivo.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE196734 | GEO | 2023/02/14

REPOSITORIES: GEO