Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq]

ABSTRACT: We find that, in contrast to most cancer types, beta-catenin activation in preB-ALL cells supresses proliferation and leads to cell death. Proteomic analyses indicate that unlike in solid tumors beta-catenin interacts with Ikaros factors (IKZF1 and IKZF3) in pre-B cells. In order to examine the interaction between IKZF1/IKZF3 and beta-catenin we performed ChIPseq to assay chromatin state and TF binding in CTNNB1-GOF and IKZF1/3-LOF conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE196745 | GEO | 2025/08/08

REPOSITORIES: GEO