Transcriptomics,Genomics

Dataset Information

21

MicroRNA expression of Ink4a/Arf-/- Pten-/- mouse astrocytes


ABSTRACT: To identify QK-modulated microRNAs exhibiting a >1.5-fold change across all three cell model systems: human GBM cell lines, U87 and Hs683, and Ink4a/Arf-/- Pten-/- mouse astrocytes Overall design: Ink4a/Arf-/- Pten-/- mouse astrocytes

INSTRUMENT(S): miRCURY LNA microRNA Array, v.11.0 - hsa, mmu & rno

SUBMITTER: Hailei Zhang   

PROVIDER: GSE19692 | GEO | 2009-12-30

SECONDARY ACCESSION(S): PRJNA124003

REPOSITORIES: GEO

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Publications


Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI protein associates with and leads to the stabilization of miR-20a; miR-20a, in turn, regulates TGFβR2 and the TGFβ signaling network. This pathway circuitry is substantiated by in silico  ...[more]

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