Dataset Information


MicroRNA expression of Ink4a/Arf-/- Pten-/- mouse astrocytes

ABSTRACT: To identify QK-modulated microRNAs exhibiting a >1.5-fold change across all three cell model systems: human GBM cell lines, U87 and Hs683, and Ink4a/Arf-/- Pten-/- mouse astrocytes Overall design: Ink4a/Arf-/- Pten-/- mouse astrocytes

INSTRUMENT(S): miRCURY LNA microRNA Array, v.11.0 - hsa, mmu & rno

SUBMITTER: Hailei Zhang  

PROVIDER: GSE19692 | GEO | 2009-12-30



altmetric image


Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI protein associates with and leads to the stabilization of miR-20a; miR-20a, in turn, regulates TGFβR2 and the TGFβ signaling network. This pathway circuitry is substantiated by in silico  ...[more]

Similar Datasets

2009-12-30 | E-GEOD-19687 | ArrayExpress
2009-12-30 | GSE19687 | GEO
2009-12-30 | GSE19689 | GEO
2009-12-30 | GSE19691 | GEO
2009-02-25 | E-NCMF-22 | ArrayExpress
2007-11-15 | E-NCMF-4 | ArrayExpress
2009-08-07 | E-GEOD-17462 | ArrayExpress
2009-08-01 | GSE17462 | GEO
2017-12-08 | E-MTAB-5943 | ArrayExpress
| PRJNA124003 | ENA