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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

ABSTRACT: Aged mice (22-24 mo) underwent PoWeR for 8 weeks. RRBS on myonuclei from soleus muscles (n=3 sedentary and n=3 trained) were subjected to low-input RRBS.

ORGANISM(S): Mus musculus

PROVIDER: GSE197045 | GEO | 2022/09/24

REPOSITORIES: GEO

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

Project description:Aged mice (22-24 mo) underwent Progressive weighted wheel running (PoWeR) for 8 weeks. RNA-seq on soleus and plantaris muscles was conducted on untrained and PoWeR trained mice. RNA from soleus and plantaris of young mice (4-6 months old) was used as a comparator (Englund et al. 2021 Function)

2022-12-01 | GSE198652 | GEO

Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise.

Project description:Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume endurance/resistance exercise approach for training young mice. In the current investigation, aged mice (22-mo-old) underwent a modified version of PoWeR for 8 wk. Muscle functional, cellular, biochemical, transcriptional, and myonuclear DNA methylation analyses provide an encompassing picture of how muscle from aged mice responds to high-volume combined training. Mice run 6-8 km/d, and relative to sedentary mice, PoWeR increases plantarflexor muscle strength. The oxidative soleus of aged mice responds to PoWeR similarly to young mice in every parameter measured in previous work; this includes muscle mass, glycolytic-to-oxidative fiber type transitioning, fiber size, satellite cell frequency, and myonuclear number. The oxidative/glycolytic plantaris adapts according to fiber type, but with modest overall changes in muscle mass. Capillarity increases markedly with PoWeR in both muscles, which may be permissive for adaptability in advanced age. Comparison to published PoWeR RNA-sequencing data in young mice identified conserved regulators of adaptability across age and muscles; this includes Aldh1l1 which associates with muscle vasculature. Agrn and Samd1 gene expression is upregulated after PoWeR simultaneous with a hypomethylated promoter CpG in myonuclear DNA, which could have implications for innervation and capillarization. A promoter CpG in Rbm10 is hypomethylated by late-life exercise in myonuclei, consistent with findings in muscle tissue. PoWeR and the data herein are a resource for uncovering cellular and molecular regulators of muscle adaptation with aging.

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Exercise training induces depot-specific remodelling of protein secretion in skeletal muscle and adipose tissue of obese male mice

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

Project description:Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice

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Project description:Knock out of Dnmt3a in AgRP neurons leads to a sedentary, adiposity-prone adult phenotype associated with widespread changes in DNA methylation and gene expression.

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Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

Project description:Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

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