Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression alteration of plasma exosomal circular RNAs in OSA patients with acute myocardial infarction

ABSTRACT: This study demonstrated that there were a number of dysregulated circRNAs in exosomes from OSA with AMI patients, which might be effectively served as a promising diagnostic biomarker and therapeutic targets. Objectives: Circular RNAs (circRNAs) are recently identified as a class of non-coding RNAs that participate in the incidence of acute myocardial infarction(AMI)

ORGANISM(S): Homo sapiens

PROVIDER: GSE197137 | GEO | 2022/02/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The alteration of circulating exosomal mRNAs in acute myocardial infarction is associated with inflammation response

Project description:Background: Although many cardiovascular disease studies have focused on the characteristics of microRNAs in circulating exosomes, the profile and the potential clinical diagnostic value of plasma exosomal long RNAs (exoLRs) in acute myocardial infarction (AMI) is still unknown. Methods: In this study, exoLRs profile of 10 AMI patients, 8 stable coronary artery disease (CAD) patients, and 10 healthy individuals were achieved by exosomes isolation and RNA sequencing. Bioinformatics approaches were used to investigate the features and potential clinical value of exoLRs. Results: Exosomal messenger RNAs (mRNAs) made up a majority of the total exoLRs. Immune cell types analyzed by CIBERSORT showed that neutrophils and monocytes were significantly enriched in the AMI group which were consistent with the clinical baseline characteristic. The biological processes enrichment analyses of different exosomal mRNAs and co-expression network analysis both indicated that neutrophils activation associated processes were enriched in the AMI group. We further identified two exosomal mRNA ALPL and CXCR2 which might be served as potential biomarkers for AMI diagnosis. Conclusions: Our study explored the alteration of exoLRs in the AMI patients which was associated with the acute inflammatory response mediated by neutrophils. Exosomal mRNAs ALPL and CXCR2 might be potentially useful for AMI diagnosis.

2021-08-19 | GSE159657 | GEO

Expression alteration of plasma exosomal circular RNAs in OSA patients with acute myocardial infarction

Project description:Expression alteration of plasma exosomal circular RNAs in OSA patients with acute myocardial infarction

| PRJNA809085 | ENA

Research on the circular RNA bioinformatics in patients with acute myocardial infarction

Project description:To further development of our gene expression approach to biodosimetry, We through the detection of circular RNA (circRNA) using expression profiling chips, we searched for circRNAs related to acute myocardial infarction (AMI) and explored their relationship and possible mechanisms with AMI. The study subjects included 3 AMI patients and 3 controls, and circRNA expression profiling analysis was performed using a microarray gene chip to identify circRNAs with large differences in expression between groups and to construct a circRNA-microRNA (circRNA-miRNA) network.

2022-04-22 | GSE149051 | GEO

osa

Project description:Drosophila melanogaster osa, osa, is expressed in 3 baseline experiment(s);

| FBgn0261885 | ExpressionAtlas

osa

Project description:Drosophila melanogaster osa, osa, is differentially expressed in 8 experiment(s);

| FBgn0261885 | ExpressionAtlas

Expression data from plasma of early-onset acute myocardial infarction patients and health control

Project description:CircRNAs are a new class of noncoding RNA and play regulatory roles in a variety of human diseases. However, the clinical significance of circRNAs in early-onset acute myocardial infarction (AMI) remains unknown. Therefore, we sought to explore the expression profile of circRNAs in early-onset AMI. Microarray was used to screen differentially expressed circRNAs between early-onset AMI patients and matched healthy controls.

2025-04-10 | GSE200572 | GEO

Detection of circRNA biomarker for Acute Myocardial Infarction based on system biological analysis of RNA Expression

Project description:A series of system biological analysis are performed on RNA expression to find new effective circRNA biomarkers for AMI. Firstly, the expression level of circRNA in blood samples of patients with AMI and those with mild coronary stenosis are compared to reveal circRNAs which are involved in AMI. Then, circRNAs which are significant expressed abnormally in the blood samples of patients with AMI are selected from those circRNAs.

2021-03-26 | GSE169594 | GEO

Identification of regulatory circRNAs involved in pathogenesis of acute myocardial infarction

Project description:The circRNA array was applied to investigate the expression level of circRNAs in the blood samples of coronary arteries of AMI patients and normal persons. Differentially-expressed circRNAs and potential circRNA-miRNA networks were identified in AMI patients.

2020-11-04 | GSE160717 | GEO

Cytoplasmic DIS3 degrades circular RNAs independently of the exosome

Project description:Circular RNAs (circRNAs) are frequently generated during splicing. Their physiological roles, however, remain largely elusive. Some specific circRNAs function as microRNA (miRNA) or RNA binding protein (RBP) sponges or encode for proteins and are actively translated. Due to the lack of accessible ends, circRNAs are resistant to exonucleolytic cleavage and thus are more stable than linear RNAs. Nevertheless, circRNAs are most likely turned over by cellular degradation pathways. Here, we used a biochemical purification strategy to find nucleases that could degrade circRNAs. We identified the exosome-associated nuclease DIS3, which contains an endonucleolytic PIN domain and an exonuclease domain. We show that DIS3 can degrade circRNAs independently of the exosome in vitro. Although moderately, RNA-seq reveals that selected circRNAs are stabilized when DIS3 is reduced in vivo. Based on our data, we propose a model, in which cytoplasmic DIS3 contributes to the turnover of circRNAs in human cells.

2025-05-05 | PXD050442 | Pride

Exploration of circRNA Expression Modifications and Functional Roles in a Mouse Model of OSA-induced Liver Injury: Fresh Perspectives on Pathogenic Mechanisms

Project description:The aim of this current study is to identify the global changes of circRNAs expression in OSA-induced liver damage.

2025-05-14 | GSE282153 | GEO