ChIP-seq analysis of H3K4me1 and H3K27ac in TFAM-depleted HepG2 cells

ABSTRACT: ChIP-seq analyses were used to examine the effect of TFAM inhibition on mono-methylated H3K4 (H3K4me1) and acetylated H3K27 (H3K27ac), which are histone marks characteristic of enhancer activity. Our study revealed that c-JUN-mediated enhancer activation shapes the mitochondrial stress-associated secretory phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE197242 | GEO | 2022/09/28

REPOSITORIES: GEO