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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RNA-seq head]

ABSTRACT: To evoke further attention to the potential hazard of increasingly accumulative blue light exposure, we construct a series of in vivo Drosophila models employed for multi-omics analyses. This project includes the RNA-seq data of w1118 male adult heads.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE197370 | GEO | 2023/11/08

REPOSITORIES: GEO

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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RNA-seq whole]

Project description:To evoke further attention to the potential hazard of increasingly accumulative blue light exposure, we construct a series of in vivo Drosophila models employed for multi-omics analyses. This project includes the RNA-seq data of w1118 F1 generation male adult whole flies.

2023-11-08 | GSE197382 | GEO

5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RIP-seq whole]

Project description:To evoke further attention to the potential hazard of increasingly accumulative blue light exposure, we construct a series of in vivo Drosophila models employed for multi-omics analyses. This project includes the identification results of untargeted metabolome quantification by LC-MS/MS and the Input and m6A IP data of MeRIP-seq of w1118 male adult whole flies.

2023-11-08 | GSE197395 | GEO

"Cancersensor": Circadian Rhythms

Project description:Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched healthy subjects.

| 2132582 | ecrin-mdr-crc

<i>Period2</i> 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.

Project description: Not available

| S-EPMC5651750 | biostudies-literature

5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-08 | GSE197397 | GEO

Circadian rhythms regulate amelogenesis.

Project description: Not available

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Circadian clock controls rhythms in ketogenesis by interfering with PPARa transcriptional network

Project description:Ketone bodies, intermediates in energy metabolism and signaling, have attracted significant attention due to their role in health and disease. We performed around the clock study on ketone bodies and ketogenesis with mice on different diets. We found that caloric restriction, a dietary intervention that improves metabolism and longevity, induced high amplitude circadian rhythms in blood βOHB. The blood βOHB rhythms resulted from rhythmic ketogenesis in the liver controlled by the interaction between the circadian clock and PPAR transcriptional networks. This interaction results in transcriptional reprogramming of in beta-oxidation and ketogenesis enzymes. The reprogramming is impaired in circadian clock mutant mice. The circadian clock gated ketogenesis contributes to the diet impact on health and longevity.

2022-08-31 | GSE211975 | GEO

Circadian Rhythms in Socializing Propensity.

Project description: Not available

| S-EPMC4564240 | biostudies-literature

Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Project description: Not available

| S-EPMC4432837 | biostudies-literature

RNA-Seq of head tissue from Drosophila melanogaster Wild Type and Adar5G1dAdar-/- mutant

Project description:Purpose: Validation of Drosophila A-to-I editing sites Methods: We collected heads of 5 day old male dAdar-/- mutant (y, Adar5G1, w)26 and wild type (w1118) flies. Poly(A)+ RNA was used to prepare RNA-seq libraries which were subsequently sequenced single-end by an Illumina GAII Results:We builded a framework to identify RNA editing events using RNA-seq data alone in Drosophila. To validate whether the identified A-to-G sites were bona fide A-to-I editing events, we performed RNA-seq for the D.melanogaster wild-type strain (w1118) and for the Adar5G1 null mutant that eliminates RNA editing. We found that our method achieved high accuracy; 98.2% of all A-to-G sites showed only adenosine in the Adar5G1 sample Conclusions: We anticipate that our method will be very effective in the future to identify RNA editing events in different species. mRNA profiles of heads of 5 day old male dAdar-/- mutant (y, Adar5G1, w)26 and wild type (w1118) flies

2012-12-20 | E-GEOD-42815 | biostudies-arrayexpress

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