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Effects of peptidomimetic PD00 on OVA-induced immune cells and their metabolic pathways in mouse lung tissue by single-cell transcriptome sequencing

ABSTRACT: OVA-induced allergic asthma in mice shares many similar features with human asthma. The peptidomimetic PD00 can significantly improve OVA-induced asthma symptoms in mice. However, the molecular mechanism by which it works is still unclear. The metabolic status of immune cells affects their functional status, so single-cell transcriptome sequencing was used to explore the effect of PD00 on immune cell subsets and their metabolic pathways in OVA-treated mouse lung tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE197573 | GEO | 2025/02/16

REPOSITORIES: GEO

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