Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular signatures of the Eagle effect induced by the artificial siderophore conjugate LP-600 in E. coli

ABSTRACT: We investigated a paradoxical re-growth of E. coli upon treatment of a novel siderophore-conjugate, LP-600, at concentrations 16-32 times above the minimum inhibitory concentration (MIC).Transcriptome analysis revealed that LP-600 induced the expression of genes involved in SOS response and e14 prophage upon regrowth conditions.

ORGANISM(S): Escherichia coli

PROVIDER: GSE197880 | GEO | 2022/07/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

ECO_HILIC_neg_Ctrl_low_high_LP-600

Project description:E.coli metabolomics under treatment of different concentrations of siderophore-conjugate, LP-600.

2022-02-18 | MSV000088865 | MassIVE

ECO_HILIC_pos_Ctrl_low_high_LP-600

Project description:E.coli metabolomics under treatment of different concentrations of siderophore-conjugate, LP-600.

2022-02-18 | MSV000088864 | MassIVE

ECO_c18_neg_Ctrl_low_high_LP-600

Project description:E.coli metabolomics under treatment of different concentrations of siderophore-conjugate, LP-600.

2022-02-18 | MSV000088863 | MassIVE

Gene expression profiling of siderophore-drug resistant mutant of Pseudomonas aeruginosa PAO1

Project description:The aim of the experiment was to identify genes differentially expressed between the susceptible wild type strain P. aeruginosa PAO1 (PT5) and a mutant resistant to a drug-siderophore conjugate, in order to obtain information on the resistance mechanism(s). A mutant of PT5 able to grow at 4 mg/l BAL30072, a drug-siderophore conjugate, was selected in vitro . The susceptible wild type strain PT5 and the mutant (BAL6) were grown in LB medium and the mutant also in the presence of 4 mg/l BAL30072 to mid-exponential growth phase (OD600 =2) in triplicate cultures. RNA was extracted using the RNeasy Kit (Qiagen). A total of nine Affymterix P. aeruginosa arrays were hybridized (one for each replicate) under standard conditions.

2013-04-17 | E-MTAB-1381 | biostudies-arrayexpress

ECO_c18_pos_Ctrl_low_high_LP-600

Project description:Metabolites under treatments of siderophore-conjugate

2022-02-15 | MSV000088837 | MassIVE

Transcriptomic profiling of LP lesions, hypertrophic LP (HLP) lesions, and healthy controls

Project description:The microarray experiment was employed to evaluate the gene expressions in skin lesions of LP, hypertrophic LP (HLP), and healthy controls.

2020-01-01 | GSE130403 | GEO

RGS4 impacts carbohydrate and siderophore metabolism in Trichoderma reesei

Project description:We investigated the function of the SNX/H-type regulator of G-protein signaling (RGS) protein RGS4 and found alterations in enzyme regulation, stress response, siderophore production and metabolism of several carbon sources in light and darkness

2022-12-12 | GSE216955 | GEO