Transcriptomic study identifies quercetin and rutin as repurposed drugs for Parkinson’s Disease in in vitro 6-OHDA model

ABSTRACT: SH-SY5Y cells were treated with 6-hydroxydopamine (6-OHDA) to obtain an in vitro PD model. Transcriptome data were collected from both treated and untreated cells.We mapped significantly upregulated genes on a protein-protein interaction network to identify potential drug targets. Drugs targeting the selected drug targets were applied to 6-OHDA treated SH-SY5Y cells. Among the candidate drugs, quercetin and rutin were shown to be neuroprotective by effectively decreasing cell death.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198009 | GEO | 2023/01/01

REPOSITORIES: GEO