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Global profiling of prostate cancer cell expression upon treatment with media conditioned from human stromal cells ectopically expressing PDK4

ABSTRACT: Technical advances in next generation sequencing (NGS) has revolutionized system-based analysis of genome-wide expression, cellular pathways and responses. We performed this study to establish the transcriptomic profiles of human prostate cancer cell lines exposed to conditioned media from human primary stromal cells engineered to express pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme that is correlated with glucose metabolism, negatively regulates the conversion of pyruvate to acetyl-CoA and plays important roles in cancer progression and multiple other pathological events.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198110 | GEO | 2023/09/05

REPOSITORIES: GEO

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