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Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

ABSTRACT: We evaluated the therapeutic efficacy and transcriptome changes induced in hepatocellular carcinoma upon treatment of Lap-tTA/Tet-O-MYC transgenic mice with two Bi-steric mTORC1-selective inhibitors, sorafenib, or doxycycline to inactivate MYC via the TET system at different time points post treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE198201 | GEO | 2025/09/09

REPOSITORIES: GEO

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Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

Project description:Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

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Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

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A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer

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Study of gene expression of mouse cMET experiments

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