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Single-cell profiling of human adipose tissue-derived mesenchymal progenitor cells induced toward adipogenic fate.

ABSTRACT: To understand the specific transcriptomic changes in cells undergoing adipogenic differentiation, we performed single cell RNA-seq on two separate cultures: one corresponding to multipotent progenitors grown to confluency but not subjected to differentiation stimuli, and the second corresponding to progenitors exposed to adipogenic media for 3 days. Homogenous multipotent progenitors underwent two distinct fate trajectories rapidly upon induction of adipose differentiation, one toward the adipocyte fate, and the other towards a distinct, undifferentiated state.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198482 | GEO | 2023/04/01

REPOSITORIES: GEO

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Human adipose tissue-derived mesenchymal progenitor cells induced toward adipogenic, chondrogenic, or osteogenic induction fates.

Project description:We demonstrated the multipotent potential and change of cell identity of human adipose tissue-derived progenitors by subjecting cells to adipogenic, chondrogenic, and osteogenic induction. mRNA transcriptomic profiling results demonstrated the detection of lineage-specific markers.

2023-04-01 | GSE198275 | GEO

Time course profiling of human adipose tissue-derived mesenchymal progenitor cells induced toward adipogenic fate

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miRNA profiling during adipogenic differentiation of adipose-derived stem cells

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2016-04-11 | E-ERAD-460 | biostudies-arrayexpress

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2019-06-24 | PXD014195 | Pride

Development of gene expression signatures for contact-inhibited and adipogenic-differentiated 3T3-L1 and NIH3T3 fibroblasts

2015-05-28 | GSE69320 | GEO

Development of gene expression signatures for contact-inhibited and adipogenic-differentiated 3T3-L1 and NIH3T3 fibroblasts

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2015-05-28 | E-GEOD-69320 | biostudies-arrayexpress

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