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Transcriptome comparison between TCR γδ T subsets reveals their exclusive and shared markers

ABSTRACT: Intestinal intraepithelial gamma-delta T cells (iIEL gd T cells) constitute a peculiar subset of T lymphocytes located in the gut epithelial barrier involved in intestinal homeostasis. To date, type 1 and type 17 TCR gamma-delta T cells have been well characterized into two functional categories based on phenotypic and functional markers e.g. CD44 and CD27. However, It remains to be determined how to classify iIEL gamma T cells based on commonly used markers. We addressed this question by comparing the transcriptomes of mouse iIEL gamma-delta T cells with distinct functionally well-described gamma-delta T cells present in the periphery.

ORGANISM(S): Mus musculus

PROVIDER: GSE198703 | GEO | 2022/06/29

REPOSITORIES: GEO

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