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OFCD (Occulofciocardiodental) patient's PDL (peridontal ligament cells) and Healthy control PDL cells

ABSTRACT: Transcriptional profiling of mouse embryonic stem cells comparing Mutant PDL cells and healthy PDL cells to study Radiculomegaly (excessive dental root elongation) Two-condition experiment, Mutant vs. Healthy PDL cells, technological triplicate

ORGANISM(S): Homo sapiens

PROVIDER: GSE198708 | GEO | 2022/03/18

REPOSITORIES: GEO

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OFCD (Occulofciocardiodental) patient's PDL (peridontal ligament cells) and Healthy control PDL cells

Project description:OFCD (Occulofciocardiodental) patient's PDL (peridontal ligament cells) and Healthy control PDL cells

| PRJNA816513 | ENA

Expression genes induced by intermittent mechanical stress (MS) in human periodontal ligament (PDL) cells

Project description:Excessive MS is known to result in disappearance of the alveolar hard line, enlargement of thePDL space, and destruction of alveolar bone, leading to occlusal traumatism. The regulatory role of MS is believed to play a critical role in the process of alveolar bone remodeling. However, little is known about the effect of excessive MS on expression of osteoclastogenesis-related genes in human PDL cells. Human PDL cells were cultured in silicon chambers, which was attached to a stretching apparatus (STB-140; Strex Co. Ltd., Osaka, Japan) The cells were allowed to attach to the chamber base for 48 hours, after which uniaxial sinusoidal stretching (conditions: 60 sec/returns, resting time; 29 sec, stretch length; 1.6 mm, stretch ratio; 105%) was applied at 37°C, 5% CO2. We compared to the genes expression between 0 and 48 hours after MS stimulation.

2010-12-20 | E-GEOD-26077 | biostudies-arrayexpress

Expression genes induced by intermittent mechanical stress (MS) in human periodontal ligament (PDL) cells

2010-12-20 | GSE26077 | GEO

Comparative gene expression analysis of dental follicle and periodontal ligament in humans

Project description:The aim of this study was to evaluate and compare the gene expression profiles of dental follicle and periodontal ligament in humans, which can possibly explain their functions of dental follicle and PDL such as eruption coordination and stress resorption. That may apply this information to clinical problem like eruption disturbance and to periodontal tissue engineering. PDL samples were obtained from permanent premolars (n=11) and dental follicle samples were obtained during extraction of supernumerary teeth (n=4). Comparative cDNA microarray analysis revealed several differences in gene expression between permanent PDL and dental follicles.

2014-08-21 | E-GEOD-51342 | biostudies-arrayexpress

BMP-2-responsive genes in mouse periodontal ligament-derived PDL-L2 cells with and without endoglin knockdown

Project description:This study was designed to identify endoglin (ENG)-dependent BMP2-responsive genes in the mouse fibroblastic cell line PDL-L2. PDL-L2 cells were treated with an siRNA for endoglin (siENG) or a control siRNA (siCont). After 48hr, the cells were exposed to recombinant human BMP-2 (250 ng/ml) or vehicle and cultured for 12 hr.

2014-01-21 | E-GEOD-54220 | biostudies-arrayexpress

Comparative gene expression analysis of dental follicle and periodontal ligament in humans

2014-08-21 | GSE51342 | GEO

BMP-2-responsive genes in mouse periodontal ligament-derived PDL-L2 cells with and without endoglin knockdown

Project description:This study was designed to identify endoglin (ENG)-dependent BMP2-responsive genes in the mouse fibroblastic cell line PDL-L2.

2014-01-21 | GSE54220 | GEO

Comparative gene expression analysis of the human periodontal ligament and dental pulp in the human permanent teeth

Project description:The periodontal ligament(PDL) and dental pulp tissues of human permanent teeth have a number of differences in their developmental processes, histological characteristics and functions. It can be figured out that these differences are attributable to genetic backgrounds of their cells organized tissues. The purpose of this study was to identify the gene-expression profiles and their molecular biological differences of periodontal ligament and dental pulp tissues from the human permanent teeth.

2016-11-22 | GSE50639 | GEO

Gene expression of mice PDL , WT and Mkx KO (10 weeks and 4 weeks)

Project description:The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential for periodontal tissue homeostasis. Although the significance of the PDL is recognized, molecular mechanisms underlying PDL function are not well-known. We report that Mohawk homeobox (Mkx), a tendon-specific transcription factor, regulates PDL homeostasis by preventing its degeneration. Mkx is expressed in the mouse PDL at the age of 10 weeks and 12 months. In Mkx-/- mice, age-dependent expansion of the PDL at the maxillary 1st molar (M1) furcation area was observed. Transmission electron microscopy (TEM) revealed that Mkx-/- mice presented collagen fibril degeneration in PDL with age, while the collagen fibril diameter gradually increased in Mkx+/+ mice. PDL cells lost their shape in Mkx-/- mice, suggesting changes in PDL properties. Microarray and quantitative polymerase chain reaction (qPCR) analyses of Mkx-/- PDL revealed an increase in osteogenic gene expression and no change in PDL- and inflammatory-related gene expression. Additionally, COL1A1 and COL1A2 were upregulated in Mkx-overexpressing human PDL fibroblasts, whereas osteogenic genes were downregulated. Our results indicate that Mkx prevents PDL degeneration by regulating osteogenesis. Mohawk transcription factor is essential for homeostasis of the periodontal ligament by regulating osteogenic changes with age.

2017-01-17 | GSE92331 | GEO

scRNA-seq analysis of murine periodontal ligament

Project description:Periodontal tissue supports teeth in the alveolar bone socket via fibrous attachment of the periodontal ligament (PDL). The PDL contains many stromal cell types, including osteoblasts, cementoblasts, periodontal fibroblasts, and stem/progenitor cells. However, the characteristics and lineage hierarchy of each cell type remain poorly defined. Here we present a single-cell atlas of PDL, highlighting diverse cell populations in PDL.

2022-09-28 | GSE197828 | GEO

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