Transcriptional Dynamics of Motor Neuron Maturation in vivo and in vitro

ABSTRACT: Mouse spinal motor neurons are specified in the embryo on embrynic day 9.5 (E9.5), but motor function doesn't fully mature till the third week of postnatal life (P14-P21) and the degenerative disease Amyotrophic Lateral Sclerosis only affects motor neurons in adulthood (age of onset differs between models). In order to better understand motor neuron maturation, we have generated a temporal map of motor neuron transcriptional states at E10.5, E13.5, P4, P13, P21, P56, 2yr. In addition we have also profiled stem cell derived motor neurons that were co-cultured with astrocytes at DIV0, DIV7, DIV28.

ORGANISM(S): Mus musculus

PROVIDER: GSE198767 | GEO | 2022/08/02

REPOSITORIES: GEO