Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

LncRNA CHROMR regulates antiviral immunity in humans [ChIRP-Seq]

ABSTRACT: Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROMR. We established that CHROME is most highly transcribed in human macrophages treated with influenza virus and/or polyIC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198808 | GEO | 2022/08/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

LncRNA CHROME regulates the interferon response to viral challenge [COVID]

Project description:Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROME. We established that CHROME is most highly transcribed in human macrophages treated with influenza virus and/or polyIC.

2022-08-23 | GSE191238 | GEO

LncRNA CHROME regulates the interferon response to viral challenge [RNA-Seq]

2022-08-23 | GSE190074 | GEO

LncRNA CHROME regulates the interferon response to viral challenge [ChIP-Seq]

2022-08-23 | GSE190412 | GEO

LncRNA CHROME regulates the interferon response to viral and bacterial challenge [RNA-Seq]

2022-08-23 | GSE163622 | GEO

Expression analysis of genes modulated after knock-down of lncRNA CHROME.

Project description:Thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome, many of which are not conserved in lower mammals. The majority of these lncRNAs remain functionally uncharacterized and may have important implications in human physiology and disease. Here, we identify a primate-specific lncRNA, CHROME, which is increased in the plasma and atherosclerotic plaques of individuals with coronary artery disease compared to healthy controls. Using a loss-of-function approach, we show that CHROME functions as a competing endogenous RNA of microRNAs and regulates the concentration and biological functions of target genes.

2018-09-20 | GSE97469 | GEO

Human lncRNA NRAV regulates antiviral response by modulating ISGs expression during influenza A virus infection

Project description:Human lncRNA NRAV-overexpression in A549 cells was found to increase the influenza virus WSN replication. To discover the mechanism underlying this promotion by NRAV, genome-wide mRNA expression was measured by using microarray. Thousands of genes were differentially expressed and some ISGs were down-regulated. Human lncRNA NRAV-overexpressioning A549 cells (Test) and empty vector control cells were infected with influenza virus A/WSN/33 (H1N1) for 16 hours at a MOI of 3. Six total RNA samples from three independent experiments were extracted and used for mRNA microarray.

2014-11-26 | E-GEOD-48874 | biostudies-arrayexpress

LncRNA <i>Malat1</i> inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity.

Project description: Not available

| S-EPMC7519350 | biostudies-literature

Human lncRNA NRAV regulates antiviral response by modulating ISGs expression during influenza A virus infection

2014-11-26 | GSE48874 | GEO

ORAI1 is required for T cell mediated allergic airway inflammation but not antiviral immunity in the lung

Project description:This study investigates the role of store-operated calcium entry (SOCE) in T cell-mediated immune responses to pulmonary influenza A virus (IAV) infection and allergic airway inflammation after immunization by house dust mite (HDM) allergens. We conducted a comparative gene expression analysis of antigen-specific CD4+ T cells from wildtype (WT) and Orai1fl/fl Cd4Cre mice that were adoptively transferred to TCRalpha knockout mice followed by sensitization / challenge with HDM or infection with influenza A virus (IAV) strain x31. Donor CD4+ T cells were isolated from the lungs of host mice at days 9 (IAV) and 14 (HDM), RNA was isolated and processed for bulk RNA sequencing.

2022-05-01 | GSE184228 | GEO

LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

Project description:In this study, we performed RNA-seq to seek lncRNAs which changed significantly on expression in RAW264.7 cells before and after vesicular stomatitis virus (VSV) infection. For further investigation, we used iCLIP-seq technologies to identify the exact interaction sites between TDP43 protein and long non-coding RNA malat1 in mouse macrophages.

2020-06-10 | GSE134032 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data