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Meteorin in macrophages regulates hematopoietic stem/progenitor cells

ABSTRACT: We show that meteorin (Metrn) from hypoxic macrophages restrains hematopoietic stem cells (HSCs) proliferation and mobilization. In macrophages specific Metrn knockout mice, reactive oxygen species levels in HSCs were upregulated through activating phospholipase C signaling. Macrophage specific knockout mice for Metrn (Metrn-fl/fl*LysM-Cre) were generated. Transcriptome profiling (RNA-Seq) and differential gene expression analysis of bone marrow LSK (lin- sca-1+ c-kit+) cells from Metrn-fl/fl*LysM-Cre (Metrn-cKO) and Metrn-fl/fl mice was performed. Metrn cKO mice showed a regulatory role for HSPCs by macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE198825 | GEO | 2023/08/04

REPOSITORIES: GEO

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Knockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage

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2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress

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Knockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage

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Immune-Responsive Gene 1 expression in myeloid cells prevents neutrophil mediated immunopathology during Mycobacterium tuberculosis infection [macrophage]

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2016-07-22 | E-GEOD-72966 | biostudies-arrayexpress

The regulatory roles of Ezh2 in response to lipopolysaccharide (LPS) in macrophages and mice with conditional Ezh2 deletion with LysM-Cre system

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