Hippocampus and visceral adipose tissues cellular landscape profiling to characterize the effects of obesity-amyloidosis comorbidity [scRNA-seq]

ABSTRACT: To explore the link between Alzheimer's disease (AD) and obisity, we profiled the transcriptional changes of the co-morbidites as well as indivitual morbidities on brain, immune and adipose tissue, at the single cell level. We observed effects of both morbidities, including AD-associated alterations in microglia and astrocytes in AD mice, and HFD-associated transcriptional changes in teh brain and the adipose. See details in: doi: https://doi.org/10.1101/2022.02.05.479219

ORGANISM(S): Mus musculus

PROVIDER: GSE198835 | GEO | 2023/01/23

REPOSITORIES: GEO