BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (ATAC III)

ABSTRACT: We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE198894 | GEO | 2022/04/24

REPOSITORIES: GEO