Genomics

Dataset Information

0

Steroidogenic factor 1 regulates transcription of the inhibin B co-receptor in pituitary gonadotrope cells


ABSTRACT: The inhibins control reproduction by suppressing follicle-stimulating hormone synthesis by pituitary gonadotrope cells. The recently discovered inhibin B co-receptor mediating this inhibition, TGFBR3L, is selectively and highly expressed in gonadotropes in both mice and humans. We sought to characterize mechanisms controlling cell-specific Tgfbr3l/TGFBR3L transcription. We identified two steroidogenic factor 1 (SF-1) cis-elements in the proximal Tgfbr3l promoter in mice. Using single-nucleus ATAC-seq we find that gonadotrope-specific SF-1 (Nr5a1) knockout mice, which exhibit hypogonadotropic hypogonadism, display, contrary to controls, closed chromatin in the promoter region of theTgfbr3l gene in gonadotropes. These, and other, data collectively indicate that SF-1 directly regulates Tgfbr3l/TGFBR3L transcription, contributing to gonadotrope-specific expression of the gene.

ORGANISM(S): Mus musculus

PROVIDER: GSE198907 | GEO | 2023/03/13

REPOSITORIES: GEO

Similar Datasets

2023-07-10 | GSE216420 | GEO
2023-09-27 | GSE236653 | GEO
2011-01-31 | E-GEOD-26966 | biostudies-arrayexpress
2022-07-14 | GSE189915 | GEO
2022-07-14 | GSE190064 | GEO
2022-07-14 | GSE190060 | GEO
2022-10-28 | GSE216466 | GEO
2022-10-25 | GSE186606 | GEO
2018-11-26 | GSE122886 | GEO
2011-01-31 | GSE26966 | GEO