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PrrA modulation of Mycobacterium tuberculosis response to acidic pH and high chloride levels is critically regulated by serine/threonine protein kinases

ABSTRACT: The purpose of this study was to understand how prevention of serine/threonine protein kinase (STPK) phosphorylation of PrrA impacts PrrA modulation of M. tuberculosis transcriptional response to acidic pH and high chloride levels.

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE199000 | GEO | 2022/06/23

REPOSITORIES: GEO

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PrrA modulates Mycobacterium tuberculosis response to acidic pH and high chloride levels

Project description:The purpose of this study was to identify genes that are differentially expressed upon prrA overexpression, to reveal the impact of PrrA on global transcription in acidic pH and/or high chloride conditions.

2022-06-23 | GSE198998 | GEO

PrrA modulation of Mycobacterium tuberculosis response to nitric oxide is critically regulated by serine/threonine protein kinases

Project description:The purpose of this study was to understand how prevention of serine/threonine protein kinase (STPK) phosphorylation of PrrA impacts PrrA modulation of M. tuberculosis transcriptional response to nitric oxide.

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PrrA modulation of Mycobacterium tuberculosis response to acidic pH and high chloride levels is critically regulated by serine/threonine protein kinases

Project description:PrrA modulation of Mycobacterium tuberculosis response to acidic pH and high chloride levels is critically regulated by serine/threonine protein kinases

| PRJNA817807 | ENA

PrrA modulates Mycobacterium tuberculosis response to acidic pH and high chloride levels

Project description:PrrA modulates Mycobacterium tuberculosis response to acidic pH and high chloride levels

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PrrA modulation of Mycobacterium tuberculosis response to nitric oxide is critically regulated by serine/threonine protein kinases

Project description:PrrA modulation of Mycobacterium tuberculosis response to nitric oxide is critically regulated by serine/threonine protein kinases

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Mycobacterium tuberculosis Serine/Threonine Protein Kinases.

Project description: Not available

| S-EPMC4242435 | biostudies-literature

Role of the global transcriptional regulator PrrA in R. sphaeroides 2.4.1

Project description:We performed microarray analyses to investigate the extent of genes regulated by the Prr system. We compared the transcriptome and proteome profiles of the wild type (WT) and mutant PrrA2 cells grown anaerobically, in the dark, with DMSO as electron acceptor. Approximately 25% of the genes present in the genome are PrrA-regulated, at the transcriptional level, either directly or indirectly, by ≥ 2-fold relative to wild type. The genes affected are widespread throughout all COG functional categories, with previously unsuspected “metabolic” genes affected when in the PrrA mutant background. PrrA was found to act both as an activator and a repressor of transcription, with more genes being repressed in the presence of PrrA (9:5 ratio). An analysis of the genes encoding the 1,536 peptides detected through our chromatographic study, which corresponds to 36% coverage of the genome, revealed that approximately 20% of the genes encoding these proteins were positively regulated, whereas approximately 32% were negatively regulated by PrrA, which is in excellent agreement with the percentages obtained for the whole genomic transcriptome profile. In addition, comparison of the transcriptome and proteome mean parameter values chosen between WT and PrrA2 showed good qualitative agreement, indicating that transcript regulation paralleled the corresponding protein abundance. The microarray analysis was validated by direct mRNA measurement of randomly selected, both positively and negatively regulated genes. lacZ transcriptional and kan translational fusions enabled us to map putative PrrA binding sites, as well as revealing gene targets for indirect regulation by PrrA.

2010-02-19 | GSE20337 | GEO

prrA mutant RNA-seq

Project description:We performed transcriptomic analysis of prrA antitoxin mutant and WT strain of the clinical isolate 39016 of Pseudomonas aeruginosa. The purpose: understanding the gene expression pattern in the mutant with and without prophage induction- in compaarison to the WT strain with and without induction.

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prrA mutant RNA-seq

Project description:prrA mutant RNA-seq

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PrrA modulates Mycobacterium tuberculosis response to nitric oxide

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