Transcriptomics,Genomics

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Long-term changes in adipose tissue gene expression following bariatric surgery


ABSTRACT: In order to identify mechanisms underlying the long-term beneficial effect of bariatric surgery on abdominal subcutaneous WAT, we performed gene microarray analyses on adipose tissue from a cohort of obese women. Adipose tissue biopsies were obtained before RYGB, and then 2 and 5 years thereafter. To evaluate the long-term effect of Roux-en-Y gastric bypass (RYGB) surgery on WAT, we also compared the WAT gene expression at 5 years postsurgery with that of age-matched nonoperated women. Overall design: Transcriptomic profiling by gene microarray was performed in abdominal subcutaneous WAT from women before (n = 50) and two (n = 49) and five (n = 38) years after Roux-en-Y gastric bypass (RYGB) surgery as well as in 28 age-matched nonoperated women.

INSTRUMENT(S): [Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version]

SUBMITTER: hui Gao  

PROVIDER: GSE199063 | GEO | 2022-04-28

REPOSITORIES: GEO

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