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RNA-seq and DIP-seq analysis of DNMTs triple knockout mESCs

ABSTRACT: DNMT1 plays a major role in embryonic development as a maintenance methyltransferase. Although recent studies have shown that DNMT1 has de novo methylation activity, the detailed role of its function during embryonic development remains unclear. In this study, to further understand the role of DNMT1 de novo methylation, we performed RNA-seq on DNMT1/3A/3B triple knockout (TKO) mESCs and TKO mESCs expressing DNMT1 (TKO_FL).

ORGANISM(S): Mus musculus

PROVIDER: GSE199124 | GEO | 2023/01/01

REPOSITORIES: GEO

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