Syndecan-2 and apoptosis in osteosarcoma

ABSTRACT: Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan during apoptosis induction. We aim to compare the modifications induced by syndecan-2 overexpression in two different human osteosarcoma cell lines using a lentiviral vector coding the human syndecan-2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19913 | GEO | 2013/09/23

SECONDARY ACCESSION(S): PRJNA122095

REPOSITORIES: GEO