SARS-COV-2 N protein hijacks host NPM1-snoRNA to enhance rRNA 2’-O-Me modification and facilitate replication

ABSTRACT: SARS-COV-2 caused COVID-19 has caused unprecedented global health crisis. Coronavirus have developed a variety of mechanisms to interfere host translation machinery to facilitate virus protein production. Here, we conducted Ribometh-seq to explore the effects of ectopic expression of SARS-COV-2 N protein on rRNA 2'-O-me modification profiles of host cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199130 | GEO | 2022/10/28

REPOSITORIES: GEO