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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE199227 | GEO | 2022/07/14

REPOSITORIES: GEO

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [scRNA-seq]

Project description:Enteric helminths form intimate physical connections with the intestinal epithelium, yet their ability to directly alter epithelial stem cell fate has not been resolved. Here we demonstrate that infection of mice with the symbiotic parasite Heligmosomoides polygyrus bakeri (Hpb), reprograms the intestinal epithelium into a fetal-like state marked by the emergence of Clusterin-expressing revival stem cells (revSCs). Organoid-based studies using parasite-derived excretory/secretory products reveal that Hpb-mediated revSC generation occurs independent of host-derived immune signals and inhibits type 2 cytokine-driven differentiation of secretory epithelial lineages that promote their expulsion. Reciprocally, type 2 cytokine signals limit revSC differentiation and, consequently, Hpb fitness indicating that helminths compete with their host for control of the intestinal stem cell niche to promote continuation of their life cycle.

2022-07-14 | GSE199226 | GEO

Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [Bulk RNA-seq]

2022-07-14 | GSE199218 | GEO