Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

ABSTRACT: Our study aims to identify transcriptional deregulation of the oculomotor transcriptome in various HD mouse models using an Affymetrix array analysis This study identified transciptome deregulation in the eye tissue of two HD mouse models, namely R6/1 and R6/2.

ORGANISM(S): Mus musculus

PROVIDER: GSE199335 | GEO | 2022/03/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

The CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington’s Disease

2014-07-15 | GSE58996 | GEO

The CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington's Disease

Project description:Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-old WT and HdhQ150 knock-in mice were generated by deep sequencing, in triplicate, using Illumina Hi-seq 2000. Conclusions: Our study showed that there is no major transcriptional deregulation in the heart of mouse models of HD. Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-old WT and HdhQ150 knock-in mice were generated by deep sequencing, in triplicate, using Illumina Hi-seq 2000.

2014-07-15 | E-GEOD-58996 | biostudies-arrayexpress

Molecular correlation between mouse retina and striatum in HD

Project description:Huntington’s disease (HD) is a devastating disorder caused by an aberrant expansion of CAG repeats in the HTT gene. Striatal dysfunction has been widely studied in HD mouse models as part of the basal ganglia, the main brain areas affected in patients that explain the most evident symptomatology. However, cumulative evidence indicates that the retina can also be functionally altered with consequences for visual function and circadian rhythms. Moreover, the retina is the most exposed part of the CNS that can be used for monitoring the health status of patients using non-invasive techniques and for treatment screenings in preclinical models. To establish the retina as an appropriate tissue for HD studies, it is first required to link retinal alterations at the cellular and molecular levels with those of the inner brain. In this work, we confirmed that the retinas of R6/1 mice were functionally and morphologically affected, and suffered a rearrangement of its transcriptome as extensive as in the striatum. Tissue-enriched genes were downregulated in both areas, but a neuroinflammation signature was specific to the R6/1 retina through the glial activation that was apparently absent in the striatum of the same animals. These phenomena were confirmed in the zQ175 strain, and were accompanied by a differential impairment of the autophagy system between both tissues that may have implications for autophagic-based therapies in HD. Overall, these results demonstrated the suitability of the retina as a research model for HD and general neurodegeneration.

2024-01-23 | GSE216520 | GEO

Memory-induced epigenome in Huntington's disease (HD) mice [ChIP-seq]

Project description:Evaluation of the effect of procedural memory using the double-H maze (DH) on striatal epigenome in HD R6/1 mice

2022-10-06 | GSE157083 | GEO

Memory-induced transcriptome in Huntington's disease (HD) mice [RNA-seq]

Project description:Evaluation of the effect of procedural memory using the double-H maze (DH) on striatal and hippocampal transcriptome in HD R6/1 mice

2022-10-06 | GSE157099 | GEO

Memory-induced 3D chromatin architecture in Huntington's disease (HD) mice [4C-seq]

Project description:Evaluation of the effect of procedural memory using the double-H maze (DH) on striatal 3D chromatin architecture in HD R6/1 mice

2022-10-06 | GSE157076 | GEO

Six-week-old R6/2 HD mouse striatum

Project description:Wild-type CBAxC57BL/6 (6 weeks of age) and HD Exon 1 R6/2 CBAxC57BL/6 (6 weeks of age). Control groups for two drug studies. All animals injected with normal saline 30-60 minutes prior to sacrifice. Keywords: parallel sample

2011-10-13 | GSE1980 | GEO

Six-week-old R6/2 HD mouse striatum

2011-10-12 | E-GEOD-1980 | biostudies-arrayexpress

Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

Project description:Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

| PRJNA819415 | ENA

Effect of IL-6 deficiency on gene expression in cell types of control and HD mouse striatum

Project description:Huntington’s disease (HD) is an incurable neurodegenerative disorder that is caused by CAG trinucleotide expansions in the huntingtin gene. However, the exact molecular and cellular mechanisms underlying the pathogenesis of HD are still not well understood. Immune signaling has been hypothesized to contribute to HD pathogenesis. In this study, we used single-nucleus RNA sequencing (snRNA-seq) to access the transcriptional profiles of striatal cell types in control and R6/2 HD model mice that either had normal levels of, or were deficient for, the cytokine interleukin-6 (IL-6). Our results provide insights into the gene expression programs that are under the control of this important immune regulator in both a normal and HD model context.

2020-05-29 | GSE143355 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data