PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

ABSTRACT: In this setup we have used RNA-seq, ChIP-seq, and ATAC-seq to identify how natural mutations in PPARg, which leads to lipodystrophy, cause changes in transcription, chromatin landscape, transcription factor binding and enhancer activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE199426 | GEO | 2022/10/27

REPOSITORIES: GEO