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Bulk RNA-seq on mouse model of diabetic nephropathy and in vitro model of SRSF7 knockdown

ABSTRACT: In this dataset, we utilized the db/db, uninephrectomy and renin-hypertension mouse model. We performed bulk RNA-seq and compared vehicle to ACE inhibitor, Rosiglitizone, SGLT2 inhibitor, ACEi + Rosiglitizone and ACEi + SGLT2i at two time points (2 days and 2 weeks). To study the mechanism, we also performed bulk RNA-seq on human primary tubular epithelial cells with or without SRSF7 siRNA knockdown.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE199437 | GEO | 2022/06/14

REPOSITORIES: GEO

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