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In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation

ABSTRACT: To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1. Gene expression and histological studies showed innate immune activation and immune cell infiltration in the intestinal lumen.

ORGANISM(S): Mus musculus

PROVIDER: GSE19946 | GEO | 2010/01/20

SECONDARY ACCESSION(S): PRJNA120179

REPOSITORIES: GEO

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