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Transcriptional profiling of the effects of HDAC4 or HDAC5 knockdown in uveal melanoma cell lines with monosomy of chromosome 3 (M3) and BAP1 mutations or disomy of chromosome 3 (D3) and wild-type BAP1

ABSTRACT: Monosomy of chromosome 3 (M3) and mutations in BAP1 are strongly associated with metastatic risk in uveal melanoma. We aimed to investigate the roles of HDAC4 and HDAC5 in uveal melanoma cell lines with differential status of chromosome 3 and BAP1. We compared gene expression after shRNA knockdown of HDAC4 or HDAC5, respectively, in two uveal melanoma cell lines with monosomy of chromosome 3 (M3) and BAP1 mutations and two uveal melanoma cell lines with disomy of chromosome 3 (D3) and wild-type BAP1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199470 | GEO | 2026/09/23

REPOSITORIES: GEO

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