Transcriptomics

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Effects of oxysterol Oxy186 and Oxy210 on A549 xenograft tumor growth


ABSTRACT: To examine the efficacy of oxysterols in inhibiting tumor growth in vivo, we tested Oxy186 and Oxy210 in subcutaneous xenograft tumor models constructed with A549 cells in nude mice. After the tumor size reached an average of ~100 mm3, the compounds were administered daily via oral gavage at 50 mg/kg. We found that Oxy186 started to inhibit tumor growth at day 8, and significantly reduced the tumor volume from day 11 to day18 of treatment, compared to that of vehicle control. Surprisingly, Oxy210 did not show such inhibitory effect.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199478 | GEO | 2022/08/01

REPOSITORIES: GEO

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