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CircRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199553 | GEO | 2022/03/30

REPOSITORIES: GEO

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circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner.

Project description:Circular RNAs are an endogenous long-lived and abundant noncoding species. Despite their prevalence, only a few circRNAs have been dissected mechanistically to date. Here, we cataloged nascent RNA-enriched circRNAs from primary human cells and functionally assigned a role to circRAB3IP in sustaining cellular homeostasis. We combined "omics" and functional experiments to show how circRAB3IP depletion deregulates hundreds of genes, suppresses cell cycle progression, and induces senescence-associated gene expression changes. Conversely, excess circRAB3IP delivered to endothelial cells via extracellular vesicles suffices for accelerating their division. We attribute these effects to an interplay between circRAB3IP and the general splicing factor SF3B1, which can affect transcript variant expression levels of cell cycle-related genes. Together, our findings link the maintenance of cell homeostasis to the presence of a single circRNA.

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circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HEK293_KD]

Project description:Circular RNAs are endogenous long-lived and abundant non-coding species. Despite their prevalence, only few circRNAs have been dissected mechanistically as regards their function to date. Here, we catalogued nascent RNA-enriched circRNAs from primary human cells and focus on circRAB3IP to assign to it a role in sustaining cellular homeostasis. We combine “omics” and functional experiments to show how circRAB3IP depletion deregulates hundreds of genes, suppress cell cycle progression, and brings about senescence-like gene expression changes. Conversely, excess circRAB3IP delivered to endothelial cells via exosomes suffices for accelerating their cell division. We attribute these effects to widespread changes in isoform usage that stem from the interplay between circRAB3IP and the general splicing factor SF3B1. Together, our findings link the maintenance of cell homeostasis to the tightly regulated titers of a single circRNA.

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Project description:circRAB3IP modulates cell proliferation by reorganizing gene expression and mRNA processing in a paracrine manner [HUVEC_KD]

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