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Single-cell RNA sequencing of small intestine neurons in Hirschsprung disease mice

ABSTRACT: This study was undertaken to identify gene expression changes in enteric neurons of Hirschsprung disease mice. Methods: We performed single-cell RNA sequencing of enteric nervous system cells isolated from the small intestine of Ednrb-knockout mice at age P14. Results: Through comparisons with published datasets of WT small intestine enteric neurons, we identify a missing neuronal population in the ganglionated small intestine of Hirschsprung disease mice. Conclusion: Single-cell RNA sequencing permits identification of cellular perturbations in Hirschsprung disease models.

ORGANISM(S): Mus musculus

PROVIDER: GSE199683 | GEO | 2022/08/24

REPOSITORIES: GEO

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