Genomics

Dataset Information

0

Cell type specific gene expression analysis in pre-symptomatic huntington's disease.


ABSTRACT: Selective neuronal vulnerability is a common, yet poorly understood characteristic of neurodegenerative diseases and is particularly prominent in Huntington's disease (HD). To determine how presence of mutant prion protein influences gene expression at pre-symptomatic stages, we used RiboTag to isolate cell type-specific, translating RNA from GABAergic, glutamatergic, somatostatin- (SST) and parvalbumin-expressing neurons of 9-month-old knock-in mice of heterozygous for a Q185 expansion in the endogenous Hdh gene or littermate controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE199837 | GEO | 2022/11/04

REPOSITORIES: GEO

Similar Datasets

2022-09-21 | GSE198063 | GEO
2019-07-01 | GSE133291 | GEO
2023-11-09 | GSE244159 | GEO
2021-05-17 | GSE144197 | GEO
2022-02-18 | GSE145521 | GEO
2016-03-17 | E-GEOD-77243 | biostudies-arrayexpress
2016-02-15 | GSE65775 | GEO
2019-10-10 | GSE138670 | GEO
2016-03-01 | GSE78793 | GEO
2016-03-01 | GSE78792 | GEO