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Transcriptome dysregulation in hepatoblastomas: the pivotal role of noncoding RNAs and detection of altered lipid metabolism

ABSTRACT: We report the application of the RNA sequencing technology for profiling gene expression alterations in hepatoblastomas. Comparing 14 hepatoblastomas to a group of control liver samples, a set of 1492 differentially expressed genes (DEGs) was detected, both coding and non-coding. We describe the enrichment of specific biological processes related to up- and downregulated genes, and the disruption of metabolic pathways including lipids, amines, and nicotinamides. Finally, we disclose a robust ncRNA transcriptome perturbation, highlighting a new epigenetic player in the control of gene expression in hepatoblastomas.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199888 | GEO | 2022/04/03

REPOSITORIES: GEO

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