Central Lung Gene Expression Associates with Myofibroblast Activity in Idiopathic Pulmonary Fibrosis

ABSTRACT: Non-fibrotic central regions of IPF lungs demonstrate massive dysregulated gene expression involving enhanced T-cell differentiation, pulmonary fibrosis idiopathic, and wound healing pathways. Enhancement of myofibroblast features without apparent extra-cellular matrix deposition in the central non-fibrotic region of IPF lungs renders a window for cell-based molecular targeting therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199949 | GEO | 2022/05/31

REPOSITORIES: GEO