Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased tumor YB-1 expression

ABSTRACT: Our aim was to gain insight into the molecular pathways that distinguish pediatric- from adult-onset glioblastomas.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20018 | GEO | 2010/01/22

SECONDARY ACCESSION(S): PRJNA124093

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression data from nine pediatric glioblastoma tumor samples

Project description:Expression data of a small series of pediatric glioblastomas were used as a control in a comparison with ependymoma tumors

2019-08-06 | GSE134404 | GEO

Proteomic analysis identified age-associated prognostic biomarkers in pneumonia-derived pediatric sepsis

Project description:Pediatric sepsis is a leading cause of mortality in children across the world. Within pediatric sepsis, how developmental age-specific host immune response impact on the occurrence and development of pediatric sepsis is still unknown, especially between infants and toddlers, which were the major susceptible age groups in sepsis. Experimental design In this study, we applied a nested case-control study strategy and analyzed the plasma proteomes of pediatric sepsis patients between infants and toddlers in comparison to their age-matched controls respectively. Each age group consists of three subgroups with different outcomes. One hundred and ten plasma samples were pooled into 16 samples for quantitative identification by LC-MS/MS. Results It was totally quantified 677 proteins. In comparison to toddlers, infant sepsis patients were characteristic with dominant neutrophil-mediated defense, suppressed adaptive immunity and NK-mediated cytotoxicity. Besides, pentose phosphate pathway was more up-regulated in infants and associated with poor outcome. Moreover, combined Hp and Thbs1 with the AUC value of 0.958 (95%CI, 0.868, 1.000) was confirmed as potential infant-adapted prognostic marker of poor outcome in sepsis. Conclusion and clinical relevance Our proteomic analysis of age-associated pediatric sepsis combined with clinical laboratory data provided a comprehensive insight into the complex, multifactorial heterogeneous host response to pediatric sepsis and allowed identification of critical differences between infant and toddler sepsis. Moreover, we confirmed that combined Hp and Thbs1 is more infant-adapted and serves as a potential prognostic biomarker for poor outcome of infant sepsis, promoting the application of age-adapted precision medicine in pediatric sepsis.

2021-11-01 | PXD026656 | Pride

RACK7 ChIP-seq in pediatric glioblastomas cell lines.

Project description:RACK7 ChIP-seq in pediatric glioblastomas cell lines.

| PRJNA574409 | ENA

AKT pathway genes define 5 prognostic subgroups in glioblastoma.

Project description: Not available

| S-EPMC4077731 | biostudies-literature

AKT pathway genes define 5 prognostic subgroups in glioblastoma

Project description:GBM samples were clusered using gene expression of AKT pathway genes to reveal at least 5 GBM AKT subtypes, having distinct DNA copy number alterations, enrichment in oncogenes and tumor suppressor genes and patterns of expression for PI3K/AKT/mTOR signaling components.

2014-09-11 | GSE61335 | GEO

microRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways

Project description:microRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways

| PRJNA150757 | ENA

Genome-wide transcriptomic analysis in pediatric glioblastomas cell lines by RNA-seq.

Project description:Genome-wide transcriptomic analysis in pediatric glioblastomas cell lines by RNA-seq.

| PRJNA574464 | ENA

Profiling of Ileal Transcriptome in Pediatric Crohn Disease

Project description:We report ileal gene expression at diagnosis in a cohort of 210 treatment-naïve patients of pediatric Crohn's disease and 35 non-IBD controls from the RISK study. After three years of follow-up after diagnosis, 27 of the CD patients progressed to complicated disease (B2 and/or B3). We aim to test whether Transcriptional Risk Scores helps to distinguish between patient subgroups, improving the predictive power gained from Genetic Risk Scores.

2017-06-20 | GSE93624 | GEO

GNPS Pediatric CF samples

Project description:A collection of oropharyngeal, skin, sputum and fecal swabs from pediatric cystic fibrosis patients.

2018-05-25 | MSV000082406 | GNPS

Genome-wide transcriptomic analysis in pediatric glioblastomas cell lines by RNA-seq.

Project description:We identified that RACK7 recognizes the histone H3.3G34R mutaion in vitro and in vivo. In order to explore the function of RACK7 and H3.3G34R mutaion, we used three pediatric glioblastomas(pGBM) cell lines. SJ-HGGx6c(R6) and SJ-HGGx42c(R42) have heterozygous G34R mutation, while SJ-HGGx39c(WT39) has wildtype H3F3A, which encodes H3.3. We next corrected H3.3G34R in R6 and R42 cells to wildtype H3.3 by CRISPR/Cas9 mediated knock-in, and knocked out RACK7 in R6 and R42 cells by CRISPR/Cas9. Finaly, we performed genome-wide transcriptomic analysis in these cell lines by RNA-seq analysis.

2020-08-10 | GSE138077 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data