Melanoma Brain Metastasis Atlas [SlideSeq]

ABSTRACT: We performed single-cell/nuclei RNA-sequencing (sc/snRNA-seq) of 22 treatment-naïve melanoma brain metastases (MBM; 5 samples using scRNA-seq and 17 snRNA-seq) from 21 patients and 10 treatment-naïve peripheral (extracranial) metastases (ECM; all snRNA-seq) from 10 patients. We performed matched spatial sequencing using SlideSeq2 (n=16) on 11 snRNA-seq samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE200278 | GEO | 2022/07/06

REPOSITORIES: GEO