Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes

ABSTRACT: We found piRNAs with different lengths represented the predominant small RNA species in oocytes from the 12 explored species, except mouse. We found endo-siRNAs resulted from the truncated Dicer isoform were mouse-specific, and os-piRNAs associating with PIWIL3 in human oocytes are widespread in mammals and are typically with low levels of the 2’-3’-O-methylation. The sequences of many highly expressed piRNA clusters are fast-evolving compared with their syntenic genomic locations, and the TE families distributing in the conserved piRNA clusters are various between species.

ORGANISM(S): Mesocricetus auratus Mus musculus Rattus norvegicus Danio rerio Sus scrofa domesticus Cavia porcellus Canis lupus familiaris Macaca fascicularis Homo sapiens Oryctolagus cuniculus Cricetulus griseus Capra hircus

PROVIDER: GSE200470 | GEO | 2024/03/06

REPOSITORIES: GEO