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Peripheral blood T helper cells circulate with pathogenic tissue resident T helper cells in chronic GVHD

ABSTRACT: Chronic graft versus host disease (cGVHD) is a systemic autoimmune-like syndrome. The role of Tph cells in the pathogenesis of cGVHD has not been examined, although previous studies have shown that cGVHD is characterized by loss of Tfh cells. Here, we show that in cGVHD patients and in a murine model that reflects characteristic features of human cGVHD, the proportions of Tph cells among CD4+ T cells in the blood were expanded. These cells augmented memory B cell differentiation and production of IgG via IL-21. Adoptive transfer experiments showed recirculation between Tph in the blood and tissue-resident T helper (Trh) cells in GVHD target tissues. The TCR repertoires of blood Tph cells and Trh cells in GVHD target tissues of mice were highly overlapping.

ORGANISM(S): Mus musculus

PROVIDER: GSE200520 | GEO | 2023/02/22

REPOSITORIES: GEO

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Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets and promotes chronic GVHD

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2024-04-30 | GSE255545 | GEO

Altered thymic NKT1 and NKT2 differentiation in murine haploidentical bone marrow transplantation with chronic GvHD

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Gene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.2)

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2010-05-15 | E-GEOD-10513 | biostudies-arrayexpress

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2010-05-15 | E-GEOD-10512 | biostudies-arrayexpress

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2008-12-21 | E-GEOD-10572 | biostudies-arrayexpress

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Gene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.2)

2008-12-22 | GSE10513 | GEO

Gene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.1)

2008-12-22 | GSE10512 | GEO

Signatures of GVHD and Relapse after Post-Transplant Cyclophosphamide Revealed by Immune Profiling and Machine Learning [17941R-18740R]

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