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Comparing the gene signature of mouse primary keratinocytes expressing a KrasG12D allele on mixed C57BL/6 :FVB/N background versus an F3 FVB/N backcross

ABSTRACT: LSL-KrasG12D mice were backcrossed with FVB/N mice and primary keratinocytes were harvested were from F1 and F3 and transduced in vitro with a Cre adenovirus to express a single mutant Kras allele. When cultures were harvested and transplanted on athymic hosts large squamous papilloma formed within 3 weeks but only from F3 keratinocyte cultures

ORGANISM(S): Mus musculus

PROVIDER: GSE200632 | GEO | 2022/11/03

REPOSITORIES: GEO

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