Genomics

Dataset Information

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Expression data from mouse basal cell carcinoma (BCC) and normal epidermis, and BCC cell line treated with cyclopamine


ABSTRACT: Activation of the Sonic hedgehog (Shh) signaling pathway due to Patched 1 (PTCH1) mutation is a key event in sporadic and familial basal cell carcinoma (BCC) development. To find out the specific pathway for therapeutic intervention, we developed a mouse BCC model by skin specific Ptch1 inactivation, and sought to identify novel Shh targets. We used microarrays to identify up-regulated genes in mouse BCC. We used microarrays to identify down-regulated genes in mouse BCC cell line by cyclopamine.

ORGANISM(S): Mus musculus

PROVIDER: GSE20065 | GEO | 2018/01/15

SECONDARY ACCESSION(S): PRJNA124177

REPOSITORIES: GEO

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