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GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE200800 | GEO | 2022/05/16

REPOSITORIES: GEO

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GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [GNAS KO]

Project description:GPR174 is abundantly expressed in B and T lymphocytes and has a role in restraining T cell responses, but the function of GPR174 in B cells is less clear. Here we report that upon in vitro culture B cells undergo a spontaneous GPR174-dependent activation process that is associated with marked changes in gene expression, including upregulation of Cd86, Nr4a1, Ccr7 and phosphodiesterases. B cells lacking Gas show a block in induction of the GPR174-dependent program. Spontaneous upregulation of CD86 in cultured B cells is dependent on protein kinase A. Both GPR174- and Gas-deficient B cells show enhanced survival in culture. In vivo, GPR174 contributes to NUR77 expression in follicular B cells and is needed for establishing a marginal zone compartment of normal size. Treatment of mice with lysophosphatidylserine (lysoPS), a GPR174 ligand, is sufficient to promote CD86 upregulation by follicular B cells. These findings demonstrate that GPR174 can signal via Gas to modulate B cell gene expression and show this can occur in vivo in response to lysoPS. Additionally, the findings illuminate a pathway that might be targeted to improve systems for the in vitro study of B cell responses.

2022-05-16 | GSE200799 | GEO

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [1 hour culture]

2022-05-16 | GSE200798 | GEO

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [0h and 4h culture]

2022-05-16 | GSE200797 | GEO

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells

Project description:GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells

| PRJNA826839 | ENA

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [GNAS KO]

Project description:GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [GNAS KO]

| PRJNA826847 | ENA

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [1 hour culture]

Project description:GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [1 hour culture]

| PRJNA826848 | ENA

GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [0h and 4h culture]

Project description:GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells [0h and 4h culture]

| PRJNA826840 | ENA

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-03 | E-GEOD-41566 | biostudies-arrayexpress

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Project description:This SuperSeries is composed of the SubSeries listed below.

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