Genomics

Dataset Information

16

MiRNA expression in thyroid cancer cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): RNG-MRC_HU25k_NICE

SUBMITTER: Kevin Lebrigand  

PROVIDER: GSE20083 | GEO | 2011-12-06

SECONDARY ACCESSION(S): GSE19933GSE19934PRJNA124279

REPOSITORIES: GEO

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Publications


The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, the aim of this study was to characterize HDACi-induced miRNAs and to determine their functional importance in the induction of cell death alone or in combination with other cancer drugs. Two HDACi, trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death in BCPAP, TPC-1, 8505C  ...[more]

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