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Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis

ABSTRACT: Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide. Accumulating evidence attests to the important roles of immune system in OA pathogenesis. Understanding the role of various immune cells in joint degeneration or joint repair after injury is helpful for improving therapeutic strategies for treating OA. Post-traumatic osteoarthritis (PTOA) develops in ~50% of individuals who have experienced an articular trauma like an anterior cruciate ligament (ACL) rupture. Here, using highly sensitive single-cell RNA sequencing technology, we delineated the temporal dynamics of immune cell accumulation in the mouse knee joint after ACL rupture.

ORGANISM(S): Mus musculus

PROVIDER: GSE200843 | GEO | 2022/07/18

REPOSITORIES: GEO

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