Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [ATAC-seq]

ABSTRACT: To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 and Olig1 positive cells in glioma pathogenesis. ATAC-seq

ORGANISM(S): Mus musculus

PROVIDER: GSE200890 | GEO | 2023/01/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [CUT&RUN]

Project description:To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 and Olig1 positive cells in glioma pathogenesis. Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for H3K27Ac in PPO1 and PPO2 mouse glioma cell lines and compare the active enhancers with oligodendrocyte progenitor cells.

2023-01-03 | GSE200891 | GEO

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_and PPO1_Cells_RNA-seq]

Project description:To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 and Olig1 positive cells in glioma pathogenesis. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 PPO2, 4 PPO1 and 2 OPN cell lines.

2023-01-03 | GSE200889 | GEO

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_Bulk_RNA-seq]

Project description:To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig1 positive cells in glioma pathogenesis and track its evolution over multiple time-points. We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 PPO1 tumor tissue with 3 Control cortex tissue.

2023-01-03 | GSE200887 | GEO

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO2_Bulk_RNA-seq]

Project description:To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 positive cells in glioma pathogenesis. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 PPO2 tumor tissue with 2 Control cortex tissue.

2023-01-03 | GSE200888 | GEO

ID4 function antagonizes OLIG1 and OLIG2 to suppressive aggressive glioma

Project description:The basic helix-loop-helix proteins Olig1 and Olig2 are expressed in high grade, aggressive human glioblastoma multiformes (GBMs). Here we investigated genetic mechanisms regulating Olig1/2 function during gliomagenesis. Although Olig2 function is necessary for early-aggressive tumor formation in a genetically relevant model of classic GBMs with intact p53 function, late-onset gliomas do eventually form. Using an unbiased approach, we identified Id4, encoding a negative HLH protein, as a gene target potently repressed by Olig2 in glioma progenitors. Although Id4 is thought to antagonize proneural genes involved in differentiation, we report a paradoxical role for Id4 in glioma. Genetic deletion of Id4 converts Olig2-/- gliomas to the early-aggressive form, and conversely, overexpression of Id4 inhibits intact Olig2 and prevents even late-onset tumors. Olig1 overexpression is sufficient for gliomagenesis in an Id4-dependent manner. Together, these findings indicate that gliomagenic factors Olig1 and Olig2 are opposed by Id4 function, which acts as tumor suppressor in p53-intact gliomas.

2018-01-02 | GSE44151 | GEO

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_Bulk_RNA-seq]

Project description:Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_Bulk_RNA-seq]

| PRJNA827151 | ENA

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [CUT&RUN]

Project description:Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [CUT&RUN]

| PRJNA827147 | ENA

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [ATAC-seq]

Project description:Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [ATAC-seq]

| PRJNA827148 | ENA

Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO2_Bulk_RNA-seq]

Project description:Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO2_Bulk_RNA-seq]