Short-term fasting releases the hematopoietic brake to promote bone marrow erythropoiesis

ABSTRACT: How our body adapts erythropoiesis to fluctuating nutrient availability is an unanswered question in hematopoietic development. Here, we demonstrate that short-term fasting triggers a sustained increase in red blood cell (RBC) production by remodeling the developmental trajectory of bone marrow megakaryocyte-erythroid progenitors (MEPs).

ORGANISM(S): Mus musculus

PROVIDER: GSE200918 | GEO | 2023/01/02

REPOSITORIES: GEO