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Distinct transcriptional programs of ascitic and solid cancer cells induce a different response to chemotherapy in high-grade serous ovarian cancer

ABSTRACT: High-grade serous ovarian cancer (HGSOC) is responsible for the largest number of ovarian cancer deaths. The frequent therapy-resistant relapses necessitate a better understanding of mechanisms driving therapy-resistance. Therefore, we mapped more than hundred thousand cells of HGSOC patients in different phases of the disease, using single-cell RNA sequencing. Within patients, we compared chemonaive with chemotreated samples. As such, we were able to create a single cell atlas of different HGSOCs lesions and their treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE201047 | GEO | 2022/07/06

REPOSITORIES: GEO

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Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer

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2023-10-09 | PXD036726 | Pride

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